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. 2017 Oct 9;8:806. doi: 10.1038/s41467-017-00920-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sex-specific delay in corticalization in female Dmp1Cre.Socs3f/f mice leads to reduced bone strength at 26 weeks of age. a, b Representative coronal cross sections of female (a) and male (b) femora showing levels of mineralization (scale at the center of the images shows red = less mineralized, while blue = more mineralized); arrows indicate approximate location of load during 3 point-bending; asterisks alongside cortical bone denote regions of poor cortical consolidation. c Cortical bone area in 26-week-old male and female Dmp1Cre (open circles) and Dmp1Cre.Socs3 ^f/f (gray squares) femora; values are mean ± SEM, n is shown below the graph. d–f Results of 3 point-bending tests of femora from 26-week-old male and female Dmp1Cre (open circles) and Dmp1Cre.Socs3 ^f/f (gray squares) femora; values are mean ± SEM, n is shown below graph (d). *p < 0.05; **p < 0.01 vs Dmp1Cre of the same sex by two-way ANOVA with Sidak post-hoc test. g Representative load-displacement curves of female Dmp1Cre (solid line) and Dmp1Cre.Socs3 ^f/f (dashed line) femora