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. 2017 Aug 24;37(4):BSR20170712. doi: 10.1042/BSR20170712

Figure 9. Role of pGlu1-CX3CL1 in HUVECs and HCASMCs.

Figure 9

Activated NF-κB increases the expression of QC and its substrate CX3CL1. pGlu formation catalysed by QC is an important post-translational step in CX3CL1 maturation. pGlu1-CX3CL1 can bind to the CX3CR1 expressed on the cell surface and activates the ERK1/2, p38 and Akt signal transduction pathways resulting in increased expression of chemokines and adhesion molecules as CX3CL1, CCL2 and ICAM1/CD54. Together, pGlu1-CX3CL1 functions as mediator and amplifier of cell migration, adhesion and proliferation.