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. 2017 Oct 9;7:12808. doi: 10.1038/s41598-017-13019-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of CD11b⁺Gr-1⁺ cells does not substantially influence the expression of pro-inflammatory factors in BAL fluid but modulates the expression in the serum. TxT mice were injected with 250 µg anti-Gr-1 antibody or 250 µg isotype-specific antibody. (a) BAL fluid and (b) serum were analysed for IL-6, G-CSF, IL-1ß, MCP-1, IFN-γ, IL-2, -5, -10 and -13 concentrations at 6, 24 and 48 h after TxT. Data present the mean value ± SD for the following numbers of mice analysed: BAL:6 h:n = 6; 24 h:n = 7; 48 h:n = 8 (TxT + Isotype), n = 6 (TxT + α-Gr-1); serum: 6 h:n = 4; 24 h:n = 10 (TxT + Isotype), n = 8 (TxT + α-Gr-1); 48 h:n = 4; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. Significance was calculated by Student’s t test comparing TxT + isotype with TxT + α-Gr-1 at each time point.