Figure 2.

Uptake of [³H]Ergothioneine by Octn1^−/− and Wild-type Mice Kidney Slices. The uptake of [³H]ergothioneine (A) and [¹⁴C] αMG (B) into Octn1^−/− (open symbol) and wild-type (closed symbol) mice kidney slices. (A) Uptake of [³H]ergothioneine into kidney slices was performed at pH 7.4 and 37 °C for 1, 3, 5, 10, 15 and 20 min in the presence (circle) or the absence (triangle) of Na⁺. (B) The uptake of [¹⁴C]αMG into kidney slices was performed at pH 7.4 and 37 °C for 5 min in the presence (open bars) or absence (closed bars) of Na⁺. Each result represents the mean ± S.E.M. (n = 3 or 4). * and ^† indicate a significant difference from the uptake in the absence of Na⁺ (p < 0.05) or Octn1^−/− mice at each time point by Student’s t-test.