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. 2017 Oct 9;7:12800. doi: 10.1038/s41598-017-13017-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan plots displaying genetic association results for 489 related individuals from the Val-de-Marne sample using a linear mixed model approach implemented in GEMMA software (A) The IFNγ-BCG phenotype across 117354 SNPs in the chromosome 8 region from 61 Mb to 91.5 Mb, and (B) The IFNγ-ESAT6_bcg phenotype across 93218 SNPs in the chromosome 3 region from 115 Mb to 139 Mb. The −log 10 value of the minimum p-value obtained in the additive, dominant and recessive tests, is displayed against chromosomal position, in Mb, in the chromosomal region concerned. A horizontal line at a −log10 p value of 5 × 10⁻⁶ indicates the significance threshold, and points in red represent the SNPs belonging to clusters investigated in more detail after replication analyses.