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. 2017 Oct 9;7:12871. doi: 10.1038/s41598-017-13265-8

Figure 6.

Figure 6

Overlap in miRNA expression between mice following chronic CS exposure and patients with COPD. (a) Differential miRNA expression was evaluated in lung tissue of mice that were exposed to 24 weeks of air or CS (n = 8 per group), and in lung tissue of current smoking patients with COPD GOLD II (n = 12) compared to never-smokers (n = 8). (b) Differential miRNA expression was evaluated in lung tissue of mice that were exposed to 24 weeks of air or CS, and in bronchial biopsies of current smoking patients with COPD GOLD II-III (n = 42) compared to ex-smoking patients with COPD GOLD II-III (n = 21). (c) Differential miRNA expression was evaluated in cell-free bronchoalveolar lavage fluid of mice that were exposed to 24 weeks of air or CS (n = 8 per group), and in induced sputum supernatant of current smoking patients with COPD GOLD I-II (n = 12) compared to never-smokers (n = 10). Numbers of differentially expressed miRNAs are represented as well as the number of overlapping miRNAs. For the overlapping miRNAs, the direction of change in expression following chronic CS exposure /current smoking and having COPD is indicated with arrows. The level of change in miRNA expression can be found in the online supplement (Tables S24). COPD: chronic obstructive pulmonary disease, GOLD: Global Initiative for Chronic Obstructive Lung Disease.