Table 2.

Differentially expressed microRNAs in murine lung tissue following 24 weeks of cigarette smoke exposure.

Up-regulated in CS-exposed mice	miRBase release 21	Fold change	Adjusted p-value
mmu-miR-135b	mmu-miR-135b-5p	13.593	0.004
mmu-miR-135a	mmu-miR-135a-5p	8.557	0.014
mmu-miR-21	mmu-miR-21a-5p	3.103	0.004
mmu-miR-155	mmu-miR-155-5p	2.274	0.004
mmu-miR-146a	mmu-miR-146a-5p	1.969	0.004
mmu-miR-138	mmu-miR-138-5p	1.908	0.007
mmu-miR-449b	mmu-miR-449c-5p	1.764	0.015
mmu-miR-31x	mmu-miR-31-3p	1.452	0.004
mmu-miR-18a	mmu-miR-18a-5p	1.435	0.046
mmu-miR-31	mmu-miR-31-5p	1.403	0.040
mmu-miR-449	mmu-miR-449a-5p	1.386	0.046
mmu-miR-342-3p	mmu-miR-342-3p	1.322	0.004
mmu-miR-200c	mmu-miR-200c-3p	1.229	0.046
mmu-miR-148a	mmu-miR-148a-3p	1.186	0.046
mmu-miR-191	mmu-miR-191-5p	1.148	0.040
Down-regulated in CS-exposed mice	miRBase release 21	Fold change	Adjusted p-value
mmu-miR-322x	mmu-miR-322-3p	1.953	0.010
mmu-miR-489	mmu-miR-489-3p	1.890	0.033
mmu-miR-1	mmu-miR-1a-3p	1.733	0.023
mmu-miR-133b	mmu-miR-133b-3p	1.553	0.033
mmu-miR-503	mmu-miR-503-5p	1.520	0.015
mmu-miR-376bx	mmu-miR-376b-5p	1.493	0.046
mmu-miR-365	mmu-miR-365-3p	1.479	0.007
mmu-miR-149	mmu-miR-149-5p	1.443	0.010
mmu-miR-503x	mmu-miR-503-3p	1.433	0.040
mmu-miR-224	mmu-miR-224-5p	1.393	0.046
mmu-miR-26a	mmu-miR-26a-5p	1.362	0.010
mmu-miR-145	mmu-miR-145a-5p	1.359	0.004
mmu-miR-676	mmu-miR-676-3p	1.302	0.023
mmu-miR-152	mmu-miR-152-3p	1.242	0.040
mmu-miR-30c	mmu-miR-30c-5p	1.241	0.046
mmu-miR-30a-5p	mmu-miR-30a-5p	1.127	0.040

First column: annotation of miRNA during microRNA profiling; Second column: annotation of miRNA according to miRBase release 21.