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. Author manuscript; available in PMC: 2017 Oct 10.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2017 Apr 17;18:389–415. doi: 10.1146/annurev-genom-083115-022515

FIGURE 3.

FIGURE 3

Adapted from (17), p. 1323.

Variants in BRCA1/2 genes associated with inherited risk of breast, ovarian and other cancers. Different databases have data on different variants, and none of these databases includes many cases from Africa, Latin America, Asia, or other populations expected to have different founder mutations and population frequency of uncommon alleles.