Table 3.
Characteristics and outcomes of patients with pure PLCIS/LCIS-PF treated with conservative surgery
| Case # N=7 |
Original Diagnosis | Review Diagnosis | ER/HER2 Status | Treatment at Time of LCIS Variant | Margins at Excision Specimen | Ipsilateral Breast Cancer | Size, Grade and Type of the Breast Cancer | Time to Event or Length of Follow-Up (months) |
|---|---|---|---|---|---|---|---|---|
| P-026 | Large Cells LCIS | PLCIS | ER+ HER2: 1+ |
Excision + CP | Close (<1mm) | DCIS | 0.2 cm; Intermediate grade; Solid and cribriform pattern | 66 |
| P-190 | PLCIS | LCIS-PF | ER+ HER2: 1+ |
Excision only | Positive | ILC classic | Multifocal lesion (1mm to 1.5cm); Grade 3; 0/5 SLNs | 45 |
| P-197 | PLCIS | PLCIS | ER+ HER2: 1+ |
Excision only | Close (<1mm) | Microinvasive ILC | One focus < 1mm (detected on MR guided biopsy); Grade not reported; 0/4 SLNs | 63 |
| P-224 | Carcinoma in situ mixed features | PLCIS | ER+ HER2: 1+ |
Excision only | Close (<1mm) | IDC | 0.9 cm; Grade 3; 0/1 SLN | 56 |
| P-209 | Apocrine PLCIS | Apocrine PLCIS | ER+ HER2: 1+ |
Excision only | Negative | N/A | N/A | 60 |
| P-301 | LCIS-PF | LCIS-PF | ER+ HER2: 1+ |
Excision only | Negative | N/A | N/A | 50 |
| P-303 | PLCIS | PLCIS | ER+ HER2: 1+ |
Excision only | Positive | N/A | N/A | 42 |
Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PLCIS, pleomorphic lobular carcinoma in situ; LCIS-PF; lobular carcinoma in situ with lobular features; DCIS, ductal carcinoma in situ; ILC, invasive lobular carcinoma; CP, chemoprevention; N/A, not applicable; SLN, sentinel lymph node