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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Clin Trials. 2017 Feb 1;14(5):432–440. doi: 10.1177/1740774517692302

Table 4.

Simulation results for designs with a control arm comparing N=250 and N = 500 in LFC scenario, p1 = p2 = p3 = pC = 0.20, p4 = 0.40. Values of = mean per-arm sample size and 95% CI are for E4.

N=250 N=500
AR(1,0) Pr(Select E4) 0.44 0.53
(95% CI ) 152(11, 201) 369 (11, 444)

AR(12,0)
Pr(Select E4) 0.46 0.67
(95% CI ) 123(11, 177) 319 (11, 413)

AR(n2N,0)
Pr(Select E4) 0.48 0.77
(95% CI ) 132(11, 179) 321 (11, 406)

AR(1, 0.1) Pr(Select E4) 0.67 0.87
(95% CI ) 127(11, 177) 313 (11, 403)

ER Pr(Select E4) 0.66 0.85
(95% CI ) 70(10, 109) 175 (13, 238)