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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Clin Trials. 2017 Feb 1;14(5):432–440. doi: 10.1177/1740774517692302

Table 5.

Simulation results for designs without a control arm in the null scenario p1 = ⋯ = p5 = 0.20, for N=250. Each ηm = Pr(NE1> NEk + m), the probability that the number of patients randomized to arm C is at least m larger than the number randomized to arm Ek. All values are per-arm.

Method Pr(Select) Pr(Stop) (95% CI) η10, η20, η30
AR(1, 0) 0.01 0.19 50 (10, 137) 0.42, 0.35, 0.28
Total 250 (250, 250)

AR(12,0)
0.01 0.26 50 (10, 110) 0.41, 0.33, 0.26
Total 249 (250, 250)

AR(n2N,0)
0.01 0.25 50 (10, 118) 0.41, 0.34, 0.27
Total 249 (250, 250)

AR(1, 0.1) 0.01 0.24 50 (10, 128) 0.41, 0.34, 0.26
Total 250 (250, 250)

ER 0.01 0.32 50 (10, 97) 0.32, 0.23, 0.2
Total 248 (250, 250)