Table 2. Multivariate linear regression analysis of the association between eGFR and SNPs.
| rs# | Near gene | Major/minor allele | Risk allelea | Coefficientb | 95%CI | P value | FDR |
|---|---|---|---|---|---|---|---|
| rs3732379 | CX3CR1 | C/T | C | 1.25 | (0.004, 2.50) | 0.049 | 0.36 |
| rs17319721 | SHROOM3 | G/A | A | -1.16 | (-2.15, -0.16) | 0.023 | 0.24 |
| rs1800591 | MTP | G/T | G | 0.99 | (0.26, 1.72) | 0.0077 | 0.13 |
| rs4744712 | PIP5K1B | C/A | A | -0.75 | (-1.31, -0.19) | 0.0088 | 0.13 |
| rs662799 | APOA5 | A/G | G | -0.61 | (-1.18, -0.046) | 0.034 | 0.29 |
| rs3782886 | BRAP | A/G | G | -1.63 | (-2.25, -1.02) | <0.0001 | <0.0001c |
| rs2467853 | SPATA5L1 | G/T | G | 2.07 | (0.89, 3.24) | 0.0006 | 0.018 c |
| rs1024611 | MCP1 | C/T | T | -0.65 | (-1.22, -0.084) | 0.025 | 0.24 |
rs#, rs number; CI, confidence interval; FDR, false discovery rate
a The allele that decreased eGFR was defined as risk allele.
b Coefficient represents the value of eGFR increase as the number of minor allele increased by 1
c FDR < 0.05.