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. 2017 Oct 10;12(10):e0186021. doi: 10.1371/journal.pone.0186021

Fig 2. Changes in gene expression induced by SHP deficiency and/or HFD feeding and myocardial histologies.

Fig 2

(A) Expression of cell growth-related genes c-jun, c-fos, and egr-1. n = 5–8 per group; * p < 0.05 compared to CD WT mice, ** p < 0.05 compared to HFD WT mice. c-jun, c-Jun-N-terminal kinase; egr-1, early growth response 1. (B) Expression of pathologic hypertrophic markers BNP, Acta1, and Serca2a, normalized to β-actin. n = 5–8 per group; * p < 0.05 compared to CD WT mice, † p < 0.05 compared to CD SHP KO mice. BNP, brain natriuretic peptide; Acta1, actin a1 skeletal muscle; Serca2a, sarco/endoplasmic reticulum Ca2+-transport ATPase2a. (C) Myocardial histology of WT and SHP KO mice. Representative myocardial sections of SHP KO mice and WT mice stained with haematoxylin and eosin (H&E). Original magnification, ×200.