Table 1. Morphometric and echocardiographic parameters of wild type and SHP KO mice fed with chow diet or high fat diet for 12 weeks.
| WT-CD (n = 5) |
WT-HFD (n = 8) |
SHP KO-CD (n = 8) | SHP KO-HFD (n = 8) | |
|---|---|---|---|---|
| Body weight (g) | 28.7 ± 1.0 | 43.5 ± 3.6 | 31.6 ± 3.4 | 38.6 ± 3.6† |
| Heart weight (mg) | 132.2 ± 10.7 | 155.6 ± 18.6 | 136.6 ± 14.8 | 134.6 ± 7.0‡ |
| Heart weight/FL (mg/mm) | 8.2 ± 0.7 | 9.6 ± 1.0 | 8.5 ± 0.1 | 8.5 ± 0.5‡ |
| LV mass (mg) | 52.8 ± 6.8 | 80.6 ± 22.5* | 76.8 ±20.5* | 73.9 ± 19.9* |
| LV mass/FL (mg/mm) | 3.3 ± 0.4 | 5.0 ± 1.4 | 4.8 ± 1.3 | 4.2 ± 0.7 |
| IVSd (mm) | 0.76 ± 0.09 | 0.76 ± 0.09 | 0.88 ± 0.10 | 0.83 ± 0.10 |
| LVPWd (mm) | 0.78 ± 0.11 | 0.89 ± 0.14 | 0.86 ± 0.15 | 0.88 ±0.13 |
| Fractional shortening (%) | 62.8 ± 5.5 | 65.9 ± 5.0 | 58.7 ± 3.3 | 63.7 ± 7.6 |
| Ejection fraction (%) | 94.6 ± 2.4 | 95.8 ± 1.7 | 92.9 ± 1.8 | 94.6 ± 3.5 |
Data are means ± SD. FL, femur length; LV, left ventricle; IVSd, Interventricular septal distance; LVPWd, Left ventricular posterior wall distance
* p < 0.05 vs. WT-CD mice.
†p < 0.05 vs. SHP KO-CD mice
‡ P < 0.05 vs. WT-HFD mice