. 2015 Mar 5;3(1):75–88. doi: 10.3390/toxics3010075

Table 1.

A selection of studies highlighting the 5-HT deficits caused by chronic l-dopa.

Model	l-Dopa concentration (mg/kg/day)	Treatment duration (days)	5-HTerigc deficit(s)	Brain region(s) affected	Reference
Rat (non-lesioned)	250	60	↓ 5-HT tissue content	STR, Cortex	Borah and Mohanakumar [63]
Rat (unilateral 6-OHDA)	12	10	↓ 5-HT tissue content	STR, Cortex STR, HIPP, SNr, PFC	Navailles et al. [65]
Rat (unilateral 6-OHDA)	12	10	↓ 5-HT extracellular	STR, Cortex STR, HIPP, SNr, PFC	Navailles et al. [65]
Rat (unilateral 6-OHDA)	12	28	↓ 5-HT tissue content	Amygdala	Eskow-Jaunarajs et al. [66]
Rat (bilateral 6-OHDA)	12	75	↓ 5-HT tissue content	STR, Amygdala, PFC	Eskow-Jaunarajs et al. [58]
Rat (non-lesioned)	12	10	↓ 5-HT cell bodies	Dorsal DRN	Stansley and Yamamoto [17]
Rat (non-lesioned)	12	10	↓ 5-HT tissue content	Dorsal DRN, PFC	Stansley and Yamamoto [17]
Macaque (MPTP-lesioned)	40	~90 (3 months)	↓ 5-HT tissue content	STR, Motor cortex, HIPP, Amygdala	Engeln et al. [67]