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Programmed death‐ligand 1/PD‐1 interaction mediates inhibition of T‐cell mediated tumor cell killing. Blockade of PD‐L1 with nivolumab results in reactivation of T‐cell mediated tumor cell killing.
Abbreviations: CTLA‐4, cytotoxic T‐lymphocyte‐associated protein 4; MHC, major histocompatibility complex; PD‐1, programmed death 1; PD‐L1, programmed death‐ligand 1 (CD274 or B7‐H1 protein); TCR, T‐cell receptor.
