Table 3.
Weights (in the units of 1%, rounded to 2 digits) for the first 48 mutation categories for the 7 clusters in Clustering-A (see Table S4) based on unnormalized (columns 2–8) and normalized (columns 9–15) regressions with the exposures computed via geometric means (see Section 2.6 for details). Here “weights based on unnormalized regressions” are given by (13), (14) and (19), while “weights based on normalized regressions” are given by (17), (14) and (21). Other conventions are the same as in Table 1.
| Mutation | Cl-1 | Cl-2 | Cl-3 | Cl-4 | Cl-5 | Cl-6 | Cl-7 | Cl-1 | Cl-2 | Cl-3 | Cl-4 | Cl-5 | Cl-6 | Cl-7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACAA | 0.00 | 0.00 | 0.00 | 6.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.54 | 0.00 | 0.00 | 0.00 |
| ACCA | 0.00 | 0.00 | 0.00 | 0.00 | 6.16 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.20 | 0.00 | 0.00 |
| ACGA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.05 |
| ACTA | 0.00 | 0.00 | 0.00 | 0.00 | 6.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.44 | 0.00 | 0.00 |
| CCAA | 0.00 | 0.00 | 0.00 | 0.00 | 8.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 8.27 | 0.00 | 0.00 |
| CCCA | 0.00 | 0.00 | 0.00 | 0.00 | 6.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.77 | 0.00 | 0.00 |
| CCGA | 0.00 | 0.00 | 7.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 7.24 | 0.00 | 0.00 | 0.00 | 0.00 |
| CCTA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.76 | 0.00 |
| GCAA | 4.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.68 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCCA | 0.00 | 0.00 | 0.00 | 0.00 | 4.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.75 | 0.00 | 0.00 |
| GCGA | 0.00 | 13.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 13.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCTA | 0.00 | 0.00 | 0.00 | 0.00 | 5.16 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.22 | 0.00 | 0.00 |
| TCAA | 0.00 | 0.00 | 0.00 | 6.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.20 | 0.00 | 0.00 | 0.00 |
| TCCA | 0.00 | 0.00 | 0.00 | 0.00 | 8.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 9.08 | 0.00 | 0.00 |
| TCGA | 0.00 | 11.96 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TCTA | 0.00 | 0.00 | 0.00 | 8.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 8.01 | 0.00 | 0.00 | 0.00 |
| ACAG | 0.00 | 0.00 | 0.00 | 0.00 | 4.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.16 | 0.00 | 0.00 |
| ACCG | 0.00 | 0.00 | 8.12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 8.17 | 0.00 | 0.00 | 0.00 | 0.00 |
| ACGG | 0.00 | 12.58 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ACTG | 0.00 | 0.00 | 0.00 | 0.00 | 4.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.88 | 0.00 | 0.00 |
| CCAG | 0.00 | 0.00 | 9.34 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 9.36 | 0.00 | 0.00 | 0.00 | 0.00 |
| CCCG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.97 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.04 |
| CCGG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.24 |
| CCTG | 0.00 | 0.00 | 12.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.61 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCAG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.68 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.63 |
| GCCG | 0.00 | 14.96 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 15.53 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCGG | 0.00 | 15.17 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 14.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCTG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.92 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.94 |
| TCAG | 0.00 | 0.00 | 0.00 | 0.00 | 9.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 8.99 | 0.00 | 0.00 |
| TCCG | 0.00 | 0.00 | 0.00 | 0.00 | 4.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.90 | 0.00 | 0.00 |
| TCGG | 0.00 | 8.53 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 8.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TCTG | 0.00 | 0.00 | 0.00 | 0.00 | 13.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.56 | 0.00 | 0.00 |
| ACAT | 0.00 | 0.00 | 0.00 | 7.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 7.73 | 0.00 | 0.00 | 0.00 |
| ACCT | 4.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ACGT | 23.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 23.33 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ACTT | 0.00 | 0.00 | 0.00 | 5.45 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.47 | 0.00 | 0.00 | 0.00 |
| CCAT | 0.00 | 0.00 | 0.00 | 6.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.02 | 0.00 | 0.00 | 0.00 |
| CCCT | 0.00 | 0.00 | 0.00 | 5.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.62 | 0.00 | 0.00 | 0.00 |
| CCGT | 17.45 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 17.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CCTT | 0.00 | 0.00 | 0.00 | 7.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 7.05 | 0.00 | 0.00 | 0.00 |
| GCAT | 0.00 | 0.00 | 0.00 | 5.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 6.00 | 0.00 | 0.00 | 0.00 |
| GCCT | 5.85 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.97 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCGT | 20.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 19.63 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GCTT | 0.00 | 0.00 | 0.00 | 5.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.92 | 0.00 | 0.00 | 0.00 |
| TCAT | 11.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TCCT | 0.00 | 0.00 | 0.00 | 7.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 7.75 | 0.00 | 0.00 | 0.00 |
| TCGT | 12.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 12.30 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TCTT | 0.00 | 0.00 | 0.00 | 9.35 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 9.27 | 0.00 | 0.00 | 0.00 |