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. 2017 Oct 10;15:204. doi: 10.1186/s12967-017-1305-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — TDAG8 gene expression reduces U937 cell attachment and migration. a Restoration of TDAG8 gene expression inhibits U937 cell attachment to matrigel. b U937 cell migration towards SDF1-α is inhibited by TDAG8 gene expression at pH 7.4 and pH 6.4. c Acidosis and restoration of TDAG8 gene expression reduces phosphorylation of paxillin at Y118 in U937 cells. d Quantification of paxillin phosphorylation at Y118 reveals a significant reduction in U937/TDAG8-luc cells at pH 7.4 and 6.4. ns: P > 0.05, *P < 0.05, P < 0.01, ***P < 0.001