Table 1.
TDAG8 gene expression is reduced significantly in blood cancers
| Leukemia | |||||||
| Source: | Rose et al. | Hafer et al. | |||||
| Cancer | CLL | TCALL | BCCALL | BALL | AML | CLL | PBALL |
| Fold change | − 3.25 | − 3.13 | − 2.497 | − 2.372 | − 2.236 | − 1.706 | − 1.317 |
| P | 2.3E−7 | 1.6E−40 | 8.1E−32 | 1.1E−26 | 1.6E−27 | 1.8E−16 | 1.6E−4 |
| N | 38 | 174 | 359 | 147 | 542 | 448 | 70 |
| Leukemia | |||||||
| Source: | Basso et al. | Aliz et al. | Stegmaier et al. | Durig et al. | |||
| Cancer | CLL | HCl | CLL | AML | TCPLL | ||
| Fold change | − 2.251 | − 1.917 | − 2.642 | − 6.115 | − 3.902 | ||
| P | 8.1E−10 | 1.6E−5 | 3.4E−5 | 1.0E−3 | 1.0E−3 | ||
| N | 12 | 16 | 12 | 9 | 6 | ||
| Lymphoma | Myeloma | ||||||
| Source: | Rose et al. | Basso et al. | Zhan et al. | ||||
| Cancer | DLBCL | FL | PEL | BL | FL | DLBCL | SM |
| Fold change | − 1.439 | − 1.354 | − 2.687 | − 1.761 | − 2.021 | − 1.874 | − 2.628 |
| P | 1.5E−2 | 3.0E−2 | 1.0E−3 | 1.5E−4 | 1.5E−6 | 1.3E−6 | 1.9E−2 |
| N | 38 | 7 | 9 | 17 | 6 | 32 | 12 |
CLL chronic lymphocytic leukemia, TCALL T-cell acute lymphoblastic leukemia, BCCALL B-cell childhood acute lymphoblastic leukemia, BALL B-cell acute lymphoblastic leukemia, AML acute myeloid leukemia, PBALL pro B-cell acute lymphoblastic leukemia, HCl hairy cell leukemia, TCPLL T-cell prolymphocytic leukemia. TDAG8 gene expression is also reduced significantly in DLBCL diffuse large B-cell lymphoma, FL follicular lymphoma, PEL pleural effusion lymphoma, BL Burkitt’s lymphoma, SM smoldering myeloma. Rose et al. normal blood cell control: B-lymphocyte (4), CD4+ T-lymphocyte (5), germinal center B-lymphocyte (1), umbilical cord blood B-lymphocyte (1), umbilical cord blood T-lymphocyte (1). Hafer et al. normal blood cell control: peripheral blood mononuclear cell (74). Basso et al. normal blood cell control: B-lymphocyte (5), centroblast (5), memory B-lymphocyte (5), naive pre-germinal center B-lymphocyte (5), small cleaved follicle center cell (5). Aliz et al. normal blood cell control: B-lymphocyte (16), CD4+ T-lymphocyte (6), centroblast (1), germinal center B-lymphocyte (2), lymph node (1), memory B-lymphocyte (3), tonsil (1). Stegmaier et al. normal blood cell control: monocyte (3), neutrophil (3). Durig et al. normal blood cell control: CD3+ peripheral blood cell (8). Zhan et al. normal blood cell control: bone marrow (22)