Fig. 7.

Co-localization of ERβ and AGO2 binding sites in the BC cell genome. a Heatmap summarizing co-localized AGO2 (green) and ERβ (red) binding sites in ERβ + (Ct- ERβ) and ERβ − (wild-type (wt)) MCF-7 cells, respectively. The right panel shows mean read densities in the four conditions displayed. b Distribution of ERβ–AGO2 binding sites with respect to the nearest transcription start site in ERβ + cells. c Observed vs expected distribution of ERβ–AGO2 binding sites within gene segments, calculated according to Genome Analyzer Tester. d Statistically enriched transcription factor binding motifs most enriched within ERβ–AGO2 binding sites