Table 6.
Adherence systems encoded by the E. coli BG1 genome
| Adherence system | Gene or genes cluster | Pathotypea | in vitro cell adherenceb | Receptor |
|---|---|---|---|---|
| Curli fimbriae | csgDEFG, csgBA | EHEC, ETEC, aEPEC, APEC | T84 | Matrix, plasma proteins |
| EhaA autotransporter | ehaA | EHEC, EAEC, ETEC, AIEC, EPEC | Primary bovine epithelial cells (terminal rectum) | Unknown |
| EhaB autotransporter | ehaB | EHEC, UPEC, ETEC, EIEC, EAEC | NAc | Collagen I, laminin |
| EhaC autotransporter | ehaC (yfaL) | EHEC, UPEC | Unknown | Unknown |
| ECP (E. coli Common Pilus) | ecpRABCDE | ETEC, EHEC, NMEC, EAEC, aEPEC, septicemia | HT29, Hep-2, HeLa, HTB-4 | Arabinosyl residues |
| ELF (E. coli Laminin-binding Fimbriae) | ycbQRST | EHEC, aEPEC | HT29, Hep-2, MDBK | Laminin |
| F9 Fimbriae | z2200-z2206 | EHEC, UPEC, APEC, AIEC, EAEC, EPEC | EBL | Bovine fibronectin, Galβ1-3GlcNAc |
| EaeH adhesin | eaeH | UPEC, EHEC, ETEC, NMEC | UM-UC-3, Caco-2, CHO, HeLa, Vero | Unknown |
| HCP (Hemorrhagic Coli Pilus) | hcpABC (ppdD-hofBC) | ETEC, EHEC, aEPEC, APEC | T84, Caco-2, HeLa, Hep-2, MDBK, cow colon explants | Laminin, fibronectin |
| Stg fimbriae | stgABCD | APEC, UPEC | UM-UC-3, INT 407 | Unknown |
| T1P (Type I pili) | fimBE, fimAICDFGH | UPEC, aEPEC, EAEC, APEC, STEC | HeLa, REC, colonic and ileal enterocytes | Mannose |
| UpaG autotransporter | upaG | UPEC | T24 | Fibronectin, laminin |
aSee the “Abbreviations” paragraph
bCell lines: T84 (human colonic adenocarcinoma), HT29 (human colorectal adenocarcinoma), Hep-2 (epithelial cells from epidermoid carcinoma of the human larynx), HeLa (human cervix epithelial carcinoma), HTB-4 (human bladder transitional carcinoma), MDBK (Madin-Darby bovine kidney), EBL (embryonic bovine lung), UM-UC-3 (human bladder carcinoma), Caco-2 (human colon carcinoma), CHO (Chinese hamster ovary), Vero (kidney epithelial cells from an African green monkey), INT 407 (HeLa derivative), REC (humen B cell lymphoma), T24 (human bladder transitional carcinoma)
cNA: no adherence to the cells lines tested