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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Cancer Lett. 2017 Sep 18;409:91–103. doi: 10.1016/j.canlet.2017.09.009

Figure 1.

Figure 1

Identification of cholesterol trafficking inhibitors in endothelial cells. (A) A schematic illustration of the screening procedure is shown. The John Hopkins Drug Library (JHDL) composed of 3,131 clinical drugs was used for screening to identify inhibitors of cholesterol trafficking in HUVEC. Finally, 13 hits were identified from primary and validation screenings. (B) HUVEC were treated with the hits for 8 h and observed under a confocal microscope after staining with filipin, a cholesterol tracer. CTRL, control; TFP, trifluoperazine; QAC, quinacrine; PCP, prochlorperazine; SLS, solasodine; TMT, tomatidine; ITRA, itraconazole; AST, astemizole; CEP, cepharanthine; NCS, niclosamide; STR, sertraline; SKF, zolantidine. Scale bar = 50 μm.