. 2016 Aug 24;32(4):429–436. doi: 10.1007/s12291-016-0605-6

Table 2.

Effect of vanillic acid on lipid proxidation markers, cytochrome P450, enzymic and non-enzymic antioxidants in normal and MNNG induced rats

Groups	Control	MNNG	VA	VA + MNNG (pre-treatment)	MNNG + VA (co-treatment)
TBARS (plasma) (mmol/dl)	2.08 ± 0.18^a	5.34 ± 0.45^d	2.02 ± 0.15^a	2.85 ± 0.17^b	3.55 ± 0.30^c
TBARS (endometrium) (mmol/mg tissue)	144.98 ± 7.41^c	111.32 ± 9.87^a	135.13 ± 7.08^c	138.45 ± 8.23^c	124.09 ± 9.74^b
LOOH (plasma) (mmol/dl)	0.8 ± 0.06^a	2.22 ± 0.12^e	0.09 ± 0.06^b	1.34 ± 0.07^c	2.03 ± 0.14^d
LOOH (endometrium) (mmol/mg tissue)	97.04 ± 7.83^a	145.89 ± 11.05^d	101.56 ± 5.54^a	119.56 ± 6.40^b	134.67 ± 7.53^c
Cytochrome p450 U^a/mg protein	9.32 ± 0.50^a	20.23 ± 1.28^c	11.25 ± 0.73^a	12.41 ± 5.23^a	16.09 ± 0.89^b
SOD (plasma) mg/dl	9.49 ± 0.59^e	4.48 ± 0.32^a	6.30 ± 0.46^c	7.39 ± 0.39^d	5.65 ± 0.41^b
SOD (endometrium) U^b/mg protein	12.61 ± 0.64^e	7.72 ± 0.39^a	11.82 ± 0.65^d	10.45 ± 0.54^c	8.79 ± 0.50^b
CAT (plasma) mg/dl	0.82 ± 0.06^c	0.54 ± 0.04^a	0.78 ± 0.06^c	0.71 ± 0.05^b	0.65 ± 0.06^b
CAT (endometrium) U^c/mg protein	2.71 ± 0.15^d	0.98 ± 0.06^a	2.08 ± 0.12^c	1.96 ± 0.10^c	1.75 ± 0.12^b
GPx (plasma) mg/dl	0.92 ± 0.05^c	0.57 ± 0.03^a	0.85 ± 0.05^c	0.87 ± 0.06^c	0.79 ± 0.07^b
GPx (endometrium) U^a/mg protein	25.21 ± 1.52^c	18.63 ± 1.01^a	24.08 ± 1.69^c	22.14 ± 1.40^b	20.39 ± 1.23^d
GSH (plasma) mg/dl	53.32 ± 2.89^d	20.74 ± 1.56^a	46.03 ± 3.22^c	47.01 ± 3.29^c	39.56 ± 2.34^b
GSH (endometrium) mg/100 g of tissue	1.54 ± 0.11^c	0.91 ± 0.06^a	1.60 ± 0.11^c	1.34 ± 0.09^b	1.29 ± 0.07^d
Vitamin C (plasma) mg/dl	3.43 ± 0.19^d	1.25 ± 0.09^a	3.24 ± 0.19^c	3.04 ± 0.21^b,c	2.84 ± 0.22^d
Vitamin C (endometrium) mg/100 g of tissue	10.54 ± 0.67^d	5.09 ± 0.32^a	10.12 ± 0.60^d	8.77 ± 0.70^c	7.95 ± 0.55^b
Vitamin E (plasma) mg/dl	2.50 ± 0.15^d	0.89 ± 0.05^a	2.95 ± 0.17^e	1.94 ± 0.11^c	1.12 ± 0.07^b
Vitamin E (endometrium) mg/100 g of tissue	8.43 ± 0.57^d	4.09 ± 0.24^a	9.84 ± 0.59^e	7.49 ± 0.39^c	6.14 ± 0.41^b

U^a = µg of GPx utilized/min. U^b = enzyme concentration required to inhibit the NBT to 10 % reduction in 1 min. U^c = µmole of H₂O₂ consumed/min. Values are means ± SD from six rats in each group. Values not sharing a common superscript differ significantly at p < 0.05 (DMRT)