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. 2017 Oct 10;7:12919. doi: 10.1038/s41598-017-13186-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network graphic for four transcription factors (TFs) and their adjacent genes. Hexagons represent known motifs. The points that form the purple circles represent genes regulated by the corresponding TF. Lines are used to indicate genes that might be regulated by the corresponding TFs. Genes located within the big circle located in the middle might be regulated by two or more TFs. Genes within the peripheral small circle might be regulated by only one TF.