Fig. 1.

Major genera in the ACVD gut microbiome. a PCA of genus-level ACVD gut microbiomes. Control samples, n = 187 (cyan); ACVD samples, n = 218 (red). For the ACVD samples (Supplementary Data 1), 205 were stable angina (circles), 8 were unstable angina (triangles), and 5 were acute myocardial infarction (AMI) (squares). Genera with the largest weights on each principal component are shown. b Relative abundances of the top 20 most abundant genera. The genus names were colored according to significant differences between the ACVD and control samples, i.e., red or cyan, q-value <0.01; light red or green, q-value <0.05; black, q-value ≥0.05, Wilcoxon rank-sum test, controlled for multiple testing. Boxes represent the median and interquartile ranges (IQRs) between the first and third quartiles; whiskers represent the lowest or highest values within 1.5 times IQR from the first or third quartiles. Circles represent all data points. c Differentially changed genera in ACVD and controls according to dbRDA based on Bray–Curtis distance. Genera with the largest weights on each principal coordinate are shown. CAP constrained analysis of principal coordinates