Fig. 2.

Mice administered with nonNAbs have higher alveolar inflammatory responses upon IAV infection. Groups of BALB/c mice (n = 3) were administered IP with indicated mAbs (15 mg per kg) and challenged IN with 5 mLD₅₀ of X31. a At 3 and 6 dpi, lung sections from naive, 2B9, FEE8, 9H10, or IgG-treated animals (n = 3 mice per group) were stained with hematoxylin and eosin. Scale bar, 100 µm. Control IgG is a murine mAb that targets GST. b Independent pathology quantification of alveolar inflammation is as indicated. Error bars represent standard error mean (SEM). c BALF were also collected from animals and analyzed for cytokine/chemokine production. A heat map was generated using GraphPad Prism. Heat map represents fold changes of cytokine/chemokine protein levels in BALF from the indicated treatments. Values are normalized to corresponding IgG controls