Fig. 5.

Heterosubtypic protection provided by human nonNAbs requires AMφ. BALB/c mice were treated IN with clodronate liposome to deplete AMφ. PBS liposome was used in non-depleted groups. Mice received 6 mg per kg (a) 5E01or (b) 5D06 IP, and then were challenged IN with 5 mLD₅₀ of X31 (H3N2). Another set of mice were administered IP with 3 mg per kg (c) 5E01 or 2 mg per kg (d) 5D06, and then challenged IN with 10 mLD₅₀ of A/Shanghai/1/13 (H7N9). The ratios in the figure legends indicate the number of animals that survived challenge over total number of animals per group. Values represent mean ± SD