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. 2017 Oct 6;11:314. doi: 10.3389/fncel.2017.00314

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Copyright © 2017 Mwangi, Kil, Phak, Park, Lim, Park and Moon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypochlorous acid contributes to cochlear injury. (A) MTT assays show that sodium hypochlorite (NaOCl) inhibits the viability of HEI-OC1 cells in a dose-dependent manner. (B) Combination of hydrogen peroxide (H₂O₂) and myeloperoxidase (MPO) augments cisplatin cytotoxicity to HEI-OC1 cells. (C) N-Acetyl-L-cysteine (NAC) and ML-171 inhibit the enhancement of cisplatin cytotoxicity by the combination of H₂O₂ and MPO. Data are mean ± SD (n = 3). ^*p < 0.05.