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. 2017 Oct 6;11:314. doi: 10.3389/fncel.2017.00314

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Copyright © 2017 Mwangi, Kil, Phak, Park, Lim, Park and Moon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Involvement of NRF2 and NR0B2 in the inhibitory effect of IL-10 on CCL2 regulation. (A) Luciferase assays show that IL-10 upregulates ARE activity in RSL cells. Quantitative RT-PCR analysis shows that RSL cells upregulate NRF2 upon exposure to CoPP (B) and HMOX1, to IL-10 (C). NR0B2 is upregulated in response to CoPP in RSL cells (D), and transfection of the adenoviral vector expressing NROB2 (Ad-Nr0b2) inhibits IL-1β-induced monocyte chemoattractant protein-1 (CCL2) upregulation (E). Ad-null: a negative control vector. Data are mean ± SD (n = 3). ^*p < 0.05.