Table 4.
Predictors of cardiovascular event risk in TGCT patients uni- and multivariable competing risk regression
| Variable | Univariable HR | 95% CI | p | Multivariable HR adjusted for age and smoking | 95% CI | p |
|---|---|---|---|---|---|---|
| Demographic characteristics | ||||||
| Age (per 5 years increase above 35 years) | 1.62 | 1.35 to 1.94 | <0.0001 | N/A | N/A | N/A |
| BMI (for 5 kg/m2 increase above 25 kg/m2) | 1.61 | 0.82 to 3.16 | 0.171 | 1.29 | 0.61 to 2.73 | 0.501 |
| Smoker or ex-smoker | 8.43 | 1.88 to 37.84 | 0.005 | N/A | N/A | N/A |
| Karnofsky index <100% | 2.65 | 0.70 to 9.99 | 0.151 | 2.28 | 0.59 to 8.87 | 0.233 |
| Diabetes pretreatment | 6.16 | 2.67 to 14.22 | <0.0001 | 2.92 | 0.96 to 8.89 | 0.06 |
| Hypertension pretreatment | 4.84 | 1.37 to 17.16 | 0.015 | 1.35 | 0.15 to 11.86 | 0.79 |
| Hyperlipidemia pretreatment | N/E | N/E | N/E | N/E | N/E | N/E |
| Diabetes posttreatment | 16.1 | 1.50 to 172.70 | 0.022 | 2.62 | 0.19 to 35.17 | 0.468 |
| Hypertension posttreatment | 37.0 | 12.78 to 107.17 | <0.0001 | 42.13 | 9.35 to 189.94 | <0.0001 |
| Hyperlipidemia posttreatment | 4.12 | 1.49 to 11.39 | 0.006 | 3.95 | 1.24 to 12.62 | 0.021 |
| Clinicopathological variables | ||||||
| TU size > 4 cm | 1.36 | 0.52 to 3.59 | 0.531 | 0.95 | 0.34 to 2.68 | 0.919 |
| Rete testis invasion | 0.53 | 0.06 to 4.87 | 0.575 | 1.01 | 0.08 to 11.96 | 0.995 |
| Rete testis invasion plus TU size > 4 cm | 1.39 | 0.18 to 10.98 | 0.755 | 0.60 | 0.07 to 4.76 | 0.626 |
| Laboratory parameters (preoperative) | ||||||
| Hemoglobin (per 1 g/dl increase) | 0.77 | 0.62 to 0.96 | 0.020 | 0.88 | 0.62 to 1.24 | 0.461 |
| Leukocytes | 1.37 | 1.13 to 1.66 | 0.001 | 1.51 | 1.15 to 1.98 | 0.003 |
| Thrombocytes (per 100 g/l increase) | 1.77 | 0.58 to 5.31 | 0.320 | 2.07 | 0.63 to 6.83 | 0.233 |
| CRP (per 10 mg/dl increase) | 1.19 | 1.12 to 1.26 | <0.0001 | 0.89 | 0.56 to 1.40 | 0.607 |
| Fibrinogen (per 100 mg/dl) | 1.78 | 1.53 to 2.07 | <0.0001 | 1.54 | 1.23 to 1.94 | 0.0001 |
| Preoperative LDH (per 100 U/l increase) | 1.12 | 0.93 to 1.35 | 0.244 | 0.62 | 0.28 to 1.39 | 0.248 |
| Laboratory parameters (postoperative) | ||||||
| CRP (per 10 mg/dl increase) | 2.18 | 1.12 to 4.24 | 0.022 | 2.31 | 0.85 to 6.27 | 0.099 |
| Laboratory parameters (1 year posttreatment) | ||||||
| CRP 1a (per 10 mg/dl increase) | 23.8 | 4.08 to 139.21 | <0.0001 | 6.45 | 0.74 to 56.22 | 0.092 |
TGCT testicular germ cell tumor, CVE cardiovascular event, BMI body mass index, N/A not applicable, N/E not explored due to low positive findings, CRP C-reactive protein, LDH lactate dehydrogenase