Fig. 2.

The role of PKC isozymes in ischaemic heart disease. Schematic diagram showing a how ischaemic preconditioning prior to prolonged ischaemia and reperfusion provides cardioprotection by activating more PKC-ε, which translocate into the mitochondria and prevents mitochondrial dysfunction induced by prolonged ischaemia and reperfusion. b In contrast, prolonged ischaemia and reperfusion result in activation of PKC-δ more than PKC-ε, leading also to translocation of PKC-δ into the mitochondria. Mitochondrial dysfunction and increase in ROS lead to both apoptosis and necrosis and severe cardiac dysfunction