Table 2.
Table showing summary of clinical trials of PKC regulators in various human diseases
| Disease | Drug | Mechanism | Ref. |
|---|---|---|---|
| Transplant rejection | Sotrastaurin | ↓PKC | [183] |
| Bipolar mania | Tamoxifen | ↓PKC (at high dose) | [184] |
| Diabetic retinopathy | Ruboxistaurin | ↓PKC-β | [186] |
| Oncology | Aprinocarsen Bryostatin Enzastaurin Midostaurin Tamoxifen |
↓PKC-α ↑PKC ↓PKC-β ↓PKC ↓PKC (at high dose) |
[188] [185, 189] [190, 191] [192] [193, 194] |
| Congestive heart failure | Flosequinan | ↓PKC | [187] |
| Coronary bypass grafting | Volatile anaesthetics Adenosine Acadesine |
↑PKC-ε ↑PKC-ε ↑PKC-ε |
[195, 196] [197, 198] [199, 200] |
| Acute myocardial infarction Salvage | Adenosine Delcasertib |
↑PKC-ε ↓PKC-δ |
[201] [202] |