Table 3.
Demographics of the cystic fibrosis (CF) and normal cohorts
| Patients with CF, median (IQR) | Control patients, median (IQR) | P-value | |
|---|---|---|---|
| Age at CT (years) | 11 (9.3–11.1) | 13.9 (8.7–15) | 0.385 |
| Age at force (years) | 11 (9.3–13) | 13.9 (8.7–15) | 0.385 |
| Time between CT and PFT (months) | 0.0 (0.0–0.0) | 0.5 (0.1–0.7) | 0.011* |
| Gender | 6 males; 5 females | 7 males; 5 females | 0.808 |
| Height (cm) | 144.4 (138.2–146.8) | 149 (136.6–170.9) | 0.296 |
| Weight (kg) | 34.5 (30.4–45.3) | 40.1 (28.6–65.8) | 0.461 |
| BMI | 17.5 (15.5–19.4) | 18.1 (15.9–20.2) | 0.435 |
| CF-CT BE score (%) | 5.2 (1.4–12.1) | 0.0 (0.0–0.7) | <0.001* |
| CF-CT AWT score (%) | 5.6 (0.0–19.3) | 0.0 (0.0–0.0) | <0.001* |
| CF-CT MP score (%) | 2.8 (0.0–22.9) | 0.0 (0.0–0.0) | <0.001* |
| CF-CT AT score (%) | 51.2 (25.9–66.7) | 3.7 (0.0–8.3) | <0.001* |
| CF-CT total score (%) | 7.8 (6.2–18.4) | 1.2 (0.4–1.4) | <0.001* |
| FEV1 (z-scores) | − -1.3 (− -2.2–0.1) | − -1.7 (− -2.1– -0.4) | 0.668 |
| FVC (z-scores) | − -0.1 (− -1.2–0.8) | − -0.4 (− -2.3–0.8) | 0.409 |
| FEV1/FVC | 0.82 (0.76–0.83) | 0.82 (0.70–0.91) | 0.385 |
| FEF25–75 (z-scores) | − -1.8 (− -2.3– -0.6) | − -1.4 (− -2.5– -1) | 0.939 |
Wilcoxon signed rank test to test the difference in demographics between the CF and control group. CF-CT scores of mucous plugging (MP), air trapping (AT), and the total score were compared as well as CF-CT scores of BE and AWT. Spirometry was compared using Z-scores according to Quanjer et al. [41]
PFT pulmonary function test, BMI body mass index, FEV 1 forced expiratory flow in 1 s, FVC forced vital capacity, FEF 25-75 forced expiratory flow during the 25-75% portion of the FVC