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. 2017 Oct 11;37(5):BSR20170718. doi: 10.1042/BSR20170718

Figure 2. PI3K/Akt pathway activity analysis.

Figure 2

Analysis of p38–MAPK pathway activity in NP cells of porcine discs subjected to different magnitudes of compression. (A) High-magnitude (1.3 MPa) compression significantly increased p38 pathway activity compared with the low-magnitude (0.1 MPa) compression. (B) The inhibitor SB203580 clearly inhibited activation of p38–MAPK pathway in NP cells both in the control group and the high-magnitude (1.3 MPa) compression group. The data are expressed as the means ± S.D., n=3. #: indicates a significant difference compared with the control group. *: indicates a significant difference between two groups (P<0.05).