Figure 1.

Positive correlation between hnRNPK and PLK1 in several types of cancer cells. (a) To examine whether hnRNPK is involved in PLK1 expression, cells from the following cancer cell lines were transfected with hnRNPK-specific siRNA: lung adenocarcinoma (A549 and H322), glioblastoma (LN229 and T98G), renal cell carcinoma (Caki1 and 786-O), colon cancer (HCT116), osteosarcoma (U2OS), and hepatocellular carcinoma (HepG2). The level of hnRNPK and PLK1 was determined by western blot. As a loading control, the level of GAPDH was examined. (b,c) To validate positive correlations, the mRNA level of hnRNPK and PLK1 in lung squamous cell carcinoma (b) and glioblastoma (c) was obtained from the TCGA database