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Survivin expression and abnormal mitotic figures. (a) Survivin staining in crypts at 24 h post 8 Gy. Large positive foci are evident in stem cells of Prkdcscid/scid/Trp53−/−mice. (b) Average number of mitotic figures per genotype at 24 h post 8 Gy IR (Unpaired t-test, *P<0.0001; ** P<0.008). (c) Representative H&E stained images of mitotic figures at 24 h post IR. Prkdcs/s=Prkdcscid/scid
