Figure 7.

Inflammatory cell death pathways restrict the expression of inhibitory receptors on primed CD8⁺ T cells. OT-1 CD8⁺ T cells (CD45.1⁺CD45.2⁺) were injected (iv, 10⁵ per mouse) into WT, RipK3-, Caspase-1,11- and Caspase-1,11-RipK3-deficient mice (all CD45.2⁺) followed by infection of recipient mice with ST-OVA (10³, i.v.) the next day. At day-6 post-infection, OT-1 cells (CD45.1⁺) were tracked in the spleens of infected recipient mice (CD45.1⁻CD45.2⁺), and the expression of various inhibitory cell surface molecules evaluated (a). The expression of various activation/inhibitory molecules was also tracked in endogenous DCs at day 6 post-infection (b). The data are shown as mean ±SEM and is representative of 2-3 separate experiments