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. 2017 Jul 21;24(11):1937–1947. doi: 10.1038/cdd.2017.119

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Copyright © 2017 The Author(s)

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Galectin-3–MUC1 interaction promotes EGRF activation in human breast epithelial cells. HCA1.7+ (a), HCA1.7− (b) and HTD(ΔCT) (c) cells were treated with EGF in the presence or absence of galectin-3 for various time before analysed by immunoblotting with antibodies against p-EGFR, EGFR and actin. Galectin-3 treatment increased EGFR activation of the full-length MUC1 transfectants HCA1.7+ and the MUC1 cytoplasmic domain-depleted transfectants HTD(ΔCT), but not of the MUC1-negative revertants HCA1.7. Densitometry scanning of the bands from three independent experiments is shown in (d–f) and is expressed as ratio p-EGFR/EGF (mean±S.E.M.). Representative blots are shown in (a–c)