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. 2017 Aug 4;24(11):1963–1974. doi: 10.1038/cdd.2017.123

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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ΔN-Bcl-xL decreases mitochondrial potential, prevented by CsA and ABT-737. (a) Immunoblot of purified Bcl-xL and ΔN-Bcl-xL proteins using anti-Bcl-xL antibody. (b) Immunoblot of purified Bcl-xL and ΔN-Bcl-xL proteins using anti-ΔN-Bcl-xL antibody. (c) Immunoblot of hippocampal neuron lysate using specific antibodies shown in a and b. (d) Immunoblot showing purity of isolated mitochondria. (e-g) TMRM fluorescence intensity in isolated mitochondria (see text for details; n=3-12 wells each from 12 rat brains). (h) Immunoblot showing cytochrome c release from isolated mitochondria (n=3). *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001, one-way ANOVA