Table 1.
Molecular features of pathogenic effector Th2 (peTh2) vs. conventional Th2 (cTh2).
| Molecule | cTh2 | peTh2 | Reference |
|---|---|---|---|
| Cytokines | |||
| IL-4 | +++ | ++++ | (9, 10, 13, 15, 29) |
| IL-5 | + | ++++ | (9, 10, 13, 15, 29, 46) |
| IL-9 | − | ++ | (10, 15) |
| IL-13 | +++ | ++++ | (9, 10, 13, 15, 29, 46) |
| IL-17 | − | + | (10) |
| IFN-γ | +/− | − | (5, 9) |
| Cytokine receptors | |||
| IL-17RB (IL-25R) | ++ | +++ | (10, 15, 46) |
| IL-1RL1 (IL-33R, ST2) | ++ | +++ | (10, 15, 18, 29, 46) |
| CRLF2 (TSLP-R) | ++ | ++++ | (10, 15) |
| Chemoattractant/homing receptors | |||
| CCR3 | + | +++ | (10) |
| CCR4 | +++ | +++ | (10) |
| CCR8 | + | +++ | (12, 13) |
| CXCR3 | + | − | (10) |
| CRTH2 | ++ | +++ | (10) |
| Transcription factors | |||
| GATA3 | +++ | ++++ | (9, 10, 12, 29) |
| T-bet | − | − | (11, 29) |
| Eomesodermin | + | − | (29) |
| Other | |||
| Hematopoietic prostaglandin D synthase | + | ++++ | (10, 15) |
| CD27 | ++ | − | (6, 9, 10, 15) |
| CD161 | + | ++++ | (10, 15) |