Table 1.
Vaccine | Lung CFUsa | Lung protection | Spleen CFUsa | Spleen protection | ||
---|---|---|---|---|---|---|
control versus BCG | control versus BCG | |||||
Control | 5.1 ± 1.27 | 4.7 ± 0.71 | ||||
BCG | 4.0 ± 0.99 | 1.1∗ | 3.7 ± 0.78 | 1.0 | ||
IFN-α | 4.8 ± 0.64 | 0.3 | 4.4 ± 0.14 | 0.3∗ | ||
BCG-IFN-α | 3.7 ± 0.37 | 1.4∗ | 0.3∗∗ | 2.8 ± 0.67 | 1.9∗ | 0.9∗∗ |
aData are represented as mean ± standard deviations of the log10 –transformed bacterial (CFUs) of M. tuberculosis per organ. Aerosol challenge. Protection is calculated with respect to control of vaccination (BCG) and with respect to PBS-immunized newborn mice (control). The data reported are ∗significant at P < 0.05 with respect to control mice and ∗∗significant at P < 0.05 with respect to BCG control of vaccination with no boost. One representative of a total of two independent experiments is shown.