Table 2.

Summary of the Philadelphia-negative MPN Cases in which TLS Developed.

Reference	Age	Sex	Diagnosis	Spleen size	Cause of TLS	Treatment for TLS	Outcome
12	63	M	blastic phase PV	spleen enlarged	spontaneously	hydration, allopurinol	died within 2 days
13	81	M	blastic phase PV	massive splenomegaly	14 days after administration of HU	hemodialysis	recovered
14	66	F	post PV myelofibrosis	massive splenomegaly	splenic irradiation	hydration, allopurinol	recovered
15	70	M	MF	marked splenomegaly	spontaneously	hemodialysis	recovered
16	47	M	PMF	extreme splenomegaly	spontanesouly, hydronephrosis due to stones in bilateral ureteral stones	bilateral ureteral stent, hydration, allopurinol	recovered
17	70	F	post PV myelofibrosis	massive splenomegaly	ruxolitinib withdrawal	hydration, sodium polystyrene sulfonate, intravenous insulin and glucose, rasburicase	recovered
This case	62	F	post PV myelofibrosis	massibe splenomegaly	ruxolitinib admisistration	hydration, sodium polystyrene sulfonate, intravenous insulin and glucose, allopurinol	recovered

PV: polycythemia vera, PMF: primary myelofibrosis, HU: Hydroxyurea