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. 2017 Oct 6;19(11):950–959. doi: 10.1016/j.neo.2017.07.010

Figure 1.

Figure 1

Figure 1

Tumor hypoxia induced by a high dose of B20.4.1.1. (A) Color-coded viable tumor pO2 maps are superimposed on the corresponding MS tissue class maps for representative animals from each treatment group (pre, 1, 2, and 3 days post treatment). The tissue classes found in the MS tissue class map are gray scale encoded as follows: dark gray – necrosis 1; light gray – subcutaneous adipose tissue; white – necrosis 2; viable tumor – underlies the color-coded viable tumor pO2 map. (B) The percent change in viable tumor volume as measured by multispectral MRI. Under the treatment of B20.4.1.1, the growth of viable tumor was significantly suppressed as compared to the control group. (C) The pO2 measured using 19F–MRI. The pO2 in viable tumor class decreased significantly in the B20-treated group on Day 3 as compared to the control group. (D) Vascular density assessed by MECA-32 histological staining. B20.4.1.1 significantly reduced the percentage of percent vascular area. (E) A representative MECA-32 histology image of the control group, vasculature staining shown in brown. (F) A representative MECA-32 histology image of the B20.4.1.1 group. #P < .05 relative to pre-treatment level, ##P < .01 relative to pre-treatment level. *P < .01 relative to control, **P < .01 relative to control.