Table 10.

Limitations and opportunities.

TYPE	Barriers/limitations	Challenges and opportunities
Experimental	Dataset	High number of subjects must be recruited to validate the results of the studies.
	Dataset	Patients with mild impairments (HY = 1) should be investigated to promote early diagnosis.
	Dataset	Age-matched controls should be involved, because motor performance vary with age.
Technological	Acceptability	The system should be developed with consideration for patients' requirements and needs.
	Usability	The system should be easy to use and eventually provide user-friendly interfaces both for clinician and patients.
	Portability and unobtrusiveness	The system should be wireless and non-invasive for use at home or outdoors without limitations for the patients. The number of sensors used and their placement over the body should address the trade-off between accuracy in measurements and obtrusiveness.
	Long-term monitoring	The system should ensure long-term operation. Long-term battery and low-power solutions have to be adopted, especially for home-monitoring applications for advanced patients with motor fluctuations.
	Measurements	The system should provide quantitative, accurate, precise, objective, and reliable measurements of the symptoms analyzed to actively support the clinician in diagnosis and management of the pathology.
		The system should be able to recognize different stages of the disease as well as to evaluate changes due to pharmacological treatments.
Clinical	Availability for use in clinical practice	- Accuracy, precision, reliability, and dependability of the system should be ensured. - Objective support for clinical examination and assessment should be validated, complying with traditional medical scales. - Improvements for patients' management should be efficiently demonstrated.