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. 2017 Oct 6;8:1260. doi: 10.3389/fimmu.2017.01260

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Copyright © 2017 Jeong, Hong, Kwon, Ghang, Hwang, Kim, Lee and Yoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Migration of monocytes in gout. (A) CD88 (C5aR) and CCR2 expression was analyzed in synovial fluid mononuclear cells. Representative flow cytometry plots are presented. (B) Correlations between levels of C5a in synovial fluid samples and numbers of white blood cells (WBC; left) or CD14⁺ cells (right) in synovial fluid from patients with acute gout attack (n = 26) were analyzed. (C) Peripheral blood mononuclear cells in the upper chamber were co-cultured with synovial fluid samples from gout patients in the presence of anti-C5a blocking antibody, anti-CCL2 blocking antibody, or isotype antibody. Migrated CD14⁺ cells were counted with flow cytometry. (D) The correlation between C5a levels in synovial fluid samples and the number of migrated CD14⁺ cells to the lower chamber is presented (n = 10).