Table 3. Association Between Midlife Cardiorespiratory Fitness and Later-life Incident Cancer and Cause-specific Mortality in CCLS.

**Health Status	Number of Events	Low Fitness	Moderate Fitness	High Fitness	1-MET increase
			Hazard Ratio* (95% Confidence Interval)	Hazard Ratio* (95% Confidence Interval)	Hazard Ratio* (95% Confidence Interval)
Healthy to Cancer	1691	referent	0.94 (0.83, 1.08)	1.07 (0.93, 1.24)	1.01 (0.99, 1.04)
Cancer to Cancer Death	219	referent	0.76 (0.53, 1.08)	0.68 (0.47, 0.98)	0.90 (0.84, 0.97)
Cancer to CVD Death	64	referent	0.59 (0.33, 1.05)	0.32 (0.16, 0.64)	0.75 (0.66, 0.87)
Healthy to Cancer Death	281	referent	0.73 (0.54, 0.98)	0.66 (0.48, 0.91)	0.96 (0.91, 1.02)
Healthy to CVD Death	495	referent	0.48 (0.39, 0.59)	0.38 (0.29, 0.48)	0.84 (0.80, 0.89)

^*Adjusted for age, visit date, BMI, smoking, systolic blood pressure, cholesterol, diabetes, fasting glucose

^**Healthy defined as having no observed incident cancer or cardiovascular disease at baseline