Table 3.
Sensitivity analysis by excluding the population with eGFR less than 30 ml/min/1.73 m2.
| Changes in proteinuria | P trend | Per degree decrease | |||
|---|---|---|---|---|---|
| Elevated proteinuria | Stable proteinuria | Reduced proteinuria | |||
| All participants | |||||
| Model 1 | 1.93 (1.66–2.23) | 1 | 0.76 (0.60–0.97) | <0.0001 | 0.71 (0.67–0.76) |
| Model 2 | 1.68 (1.45–1.95) | 1 | 0.72 (0.57–0.92) | <0.0001 | 0.75 (0.71–0.80) |
| Model 3 | 1.66 (1.43–1.93) | 1 | 0.72 (0.57–0.92) | <0.0001 | 0.75 (0.71–0.80) |
| Model 4 | 1.55 (1.34–1.81) | 1 | 0.71 (0.56–0.90) | <0.0001 | 0.78 (0.73–0.82) |
| Diabetes∗ | |||||
| Model 4 | 1.76 (1.43–2.15) | 1 | 0.73 (0.54–1.01) | <0.0001 | 0.74 (0.69–0.80) |
| Prediabetes | |||||
| Model 4 | 1.35 (1.07–1.69) | 1 | 0.71 (0.49–1.02) | 0.0005 | 0.82 (0.75–0.91) |
Model 1: adjusted for the levels of baseline proteinuria; model 2: adjusted for age, gender, and baseline proteinuria; model 3: adjusted for age, gender, level of education, income, smoking, alcohol abuse, amount of physical activity, body mass index, and baseline proteinuria; model 4: adjusted for variables in model 3 plus history of hypertension, diabetes, dyslipidemia, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, fasting plasma glucose, and creatinine. ∗The P value of interaction between proteinuria changes and diabetes for all-cause mortality is 0.3510.