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. 2017 Sep 26;2017:2320932. doi: 10.1155/2017/2320932

Table 1.

Selection of the most significantly enriched and specific GO terms in the network modules.

Module GO term (biological process) Level Total genes Mapped genes
(1) Positive regulation of interleukin-5 secretion 9 14 13
Positive regulation of interleukin-13 secretion 9 14 13
Positive regulation of T-helper 2 cell cytokine production 11 15 13
Positive regulation of interleukin-10 secretion 9 15 13

(2) JAK-STAT cascade 5 57 12
JAK-STAT cascade involved in growth hormone signaling pathway 9 26 8
Cytokine-mediated signaling pathway 6 406 15

(3) Positive regulation of neuron differentiation 7 342 6
Positive regulation of neurogenesis 7 472 6
Positive regulation of neuron projection development 8 208 5

(4) Positive regulation of leukocyte differentiation 6 137 19
Positive regulation of hemopoiesis 6 166 19
Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3 127 16

(5) MyD88-dependent toll-like receptor signaling pathway 8 92 11
Innate immune response-activating signal transduction 8 157 11

(6) Immune response-activating cell surface receptor signaling pathway 7 350 33
Antigen receptor-mediated signaling pathway 7 158 27

(7) Positive regulation of MAPK cascade 10 512 39

(8) Regulation of interleukin-12 biosynthetic process 6 16 9
Positive regulation of type I interferon production 5 57 11
Activation of innate immune response 7 170 13
Positive regulation of cytokine biosynthetic process 10 87 11
Regulation of I-kappaB kinase/NF-kappaB signaling 4 249 14

(9) Cellular response to insulin stimulus 8 255 30
Peripheral nervous system myelin maintenance 9 29 17

(10) Apoptotic signaling pathway 5 310 18

(11) Positive regulation of cell proliferation 3 964 16

(12) Transmembrane receptor protein serine/threonine kinase signaling pathway 5 273 20
Cellular response to growth factor stimulus 4 719 19