TABLE 2.

Summary of data for potentiation of GABA-activated receptors by alfaxalone, propofol, and combinations

The first column shows the concentrations of GABA and of alfaxalone (ALF) and/or propofol (Prop) applied, whereas the second column identifies the data sets shown in Figs. 3C and 4B. The column headed ∆P_o gives the mean ± S.E.M. (number of cells) for the measured P_o value produced by that potentiator or combination of potentiators, expressed as the difference from the background P_o value in the presence of 5 μM GABA (0.058). P vs. ∆P_o predicted gives the P value (one-sample t test) for the difference between the measured and predicted differences (in each case the predicted response is 0.442). The column headed ∆Sum gives the arithmetic sum of the predicted responses to the given concentration of potentiator or combinations of potentiators applied separately (e.g., 0.2 µM alfaxalone applied alone plus 2.85 µM propofol applied alone) in terms of the difference from the basal P_o value (0.058). The final column (P to ∆Sum) gives the P value for the difference between the measured response and the predicted sum.

Drugs Used	Set	∆Po	P vs. ∆Po Predicted	∆Sum	P vs. ∆Sum
5 µM GABA + 1.9 µM ALF	1	0.52 ± 0.05 (6)	0.2	0.44	0.2
5 µM GABA + 5.2 µM Prop	2	0.39 ± 0.05 (6)	0.9	0.44	0.4
5 µM GABA + 0.2 µM ALF + 2.85 µM Prop	3	0.36 ± 0.04 (6)	0.6	0.30	0.2
5 µM GABA + 0.5 µM ALF + 1.55 µM Prop	4	0.40 ± 0.04 (6)	0.7	0.28	0.04
5 µM GABA + 1 µM ALF + 0.63 µM Prop	5	0.46 ± 0.05 (6)	0.2	0.34	0.05
5 µM GABA + 1.5 µM ALF + 0.21 µM Prop	6	0.46 ± 0.05 (6)	0.2	0.40	0.2