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The fragmentation of PT domain into pieces encoded on different exons facilitates gated access to cyclization chamber (clade γ). The structural relationships are visualized on A. parasiticus PksA model (PDB: 3HRQ, chain A). Different colors correspond to fragments encoded on separate exons. The large, filled shape corresponds to the inner surface of cyclization chamber, where all exons contribute to the chamber entrance area. Views from the front (A) and back (B) are both shown.
